PhD Studentship: Stem Cell Replenishment Following Senolytic Treatment in Mice

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PhD Studentship: Stem Cell Replenishment Following Senolytic Treatment in Mice

Loughborough University

Qualification Type: PhD
Location: Loughborough
Funding for: UK Students, EU Students
Funding amount: The studentship is for 3 years and provides a tax-free stipend of £15,285 plus tuition fees at the UK/EU rate. Agreed travel between Loughborough and California and to selected scientific meetings will be funded (ca. 2-3 trips per year).
Hours: Full Time
Placed On: 10th May 2021
Closes: 31st May 2021
Reference: FP-AS-202021
 

Application details:

Reference number: FP-AS-202021

Start date of studentship: 01 July 2021

Closing date of advert: 31 May 2021

Interview date: TBC

Primary supervisor: Prof. Stolzing

Secondary supervisor: Dr. Tao

A chance for an exceptional candidate to

  • – acquire expertise in stem cells, senolytics, genetics
  • – study aging alongside world leading experts
  • – gain experience at a pioneering research lab in Silicon Valley
  • – develop interventions against age-related diseases

Full Project Detail:

This PhD project will be conducted together with the SENS Research Foundation (SRF) based in California. SRF research applies regenerative medicine to age-related disease, with the intent of repairing underlying damage. SRF research addresses unmet research needs to help build the industry that will cure the diseases of aging. Within the dynamic field of regenerative medicine, research into common malfunctions across a range of age-related diseases hold promise. Senescent cells accumulate during aging contributing to age-related diseases including cancer, dementia, and immune-aging. Drugs called ‘senolytics’ are being developed to specifically remove such cells. New drug discovery ventures have sprung up, with a considerable concentration in the San Francisco Bay Area. You will spend the majority of the research period with SRF, working in mice on senolytics & stem cells, exploring the hypothesis that a combination of senolytics with a stem cell graft could improve outcome. You will learn techniques in stem cell science, biogerontology, animal studies, & drug discovery. At specific timepoints, you will travel to Loughborough for training. Loughborough University is a top-ten rated university in England for research intensity (REF2014). You will benefit from comprehensive support and guidance from our Doctoral College, including tailored careers advice, to help you succeed in your research and future career.

You PhD supervisor, Prof. Stolzing is SRF Vice President Research & Professor in Loughborough and can help guide your progress at both locations.

Find out more:

http://www.lboro.ac.uk/study/postgraduate/supporting-you/research/

Entry requirements:

Essential:

–  a 2:1 degree in biology, cell biology, biotechnology, molecular biology, or other relevant subject.

– good laboratory & analytical skills

– good interpersonal & communication & IT skills

– willingness to work with laboratory animals

– self-motivated to conduct research, learn new methods & to critically evaluate research challenges & data integrity

– willingness to relocate to the San Francisco Bay Area

– travel to the US & UK: current COVID19 restriction permit international student travel, but you will need to be proactive in obtaining a student visa

Desirable Experience:

– animal handling & histology

– cell culture & molecular biology

– designing experiments & protocols

– research reports & scientific papers

– Statistics

Funding information:

This project is funded by the SENS Research Foundation, a non-for profit organisation. The studentship is for 3 years and provides a tax-free stipend of £15,285 plus tuition fees at the UK/EU rate. Agreed travel between Loughborough and California and to selected scientific meetings will be funded (ca. 2-3 trips per year). Other travel will need to be agreed and self-funded. There is no support for housing or other expenses.

Contact details:

Name: Prof. Alexandra Stolzing

Email address: A.Stolzing@lboro.ac.uk

How to apply:

All applications should be made online at http://www.lboro.ac.uk/study/apply/research/. Under programme name, select ‘Mechanical & Manufacturing Engineering’. Please quote reference number: FP-AS-202021